Effect of keratolytic drugs on oral hyperkeratosis in Syrian hamsters.

LE EFFECTO DE PHARACOns KERATOLYTIC SUPER HYPERKERATOSIS ORAL.-Lesiones hyperkeratotic del mucosa oral esseva inducite in albin hamsters syrian per le administration topic de 9,10-dimethyl-1,2benzanthraceno. Post 6 applicationes de un solution de 20 pro cento de acido salicylic, un significative declino quantitative esseva observate clinicamente in le keratosis. Associate alterationes microscopic del processo de keratinisation esseva le formation de un amorphe, non-laminate strato cornee, perdita de strato lucide, e disruption del strato granulose. Mucosa hyperkeratotic tractate similemente con un solution de 20 pro cento de podophyllina manifestava nulle comparabilemente significative effect keratolytic. Es stipulate que le inefficacia relative de podophyllina in le presente studio esseva conditionate per su supponite incapacitate de penetrar epithelio cornificate o per su inactivation therapeutic in le saliva alcalin del hamster.